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It's often mixed with Vegetable Glycerin (VG) in ratios like 50:50, 60:40, or 70:30 in most freebase e-liquids

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"Net nicotine use increased, but smoking continued to fall." The US, meanwhile, offered a cautionary example of unintended consequences Prof Jonathan Foulds, a professor of public health sciences at Penn State University, explained how the US Food and Drug Administration (FDA) responded to rising youth vaping and the EVALI outbreak in 2019: by banning cartridge- and pod-based e-cigarettes from the market