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Information to date would suggest TRPA1 expression is more restricted which may make for a more optimal safety profile than TRPV1 inhibition, although this remains to be seen with the increased testing of TRPA1 antagonists in both pre clinical and clinical studies

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Like light and mild Philip Morris International is promoting IQOS as safer than conventional cigarettes even though its own research shows that they are not detectably different in terms of 24 health measures