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The choice of an interval of 45 minutes between baseline and second examination in group 1 and 3 was based on a general estimate of the time necessary to reach the peak plasmatic concentration of caffeine after oral assumption, but a considerable inter-individual variability in caffeine kinetics exists [34]

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Smoking in Africa remains relatively low compared to other regions, though it varies significantly across countries and demographics: Overall prevalence among adults is estimated at 8.410.3%, with projections showing a slight declinefrom 10.3% in 2020 to around 9% by 2025