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Complications include: increased risk of bacterial and viral respiratory infections damage to the throat changes to the voice, such as hoarseness long-term cough and irritation Damage to the cilia may lead to a build-up of chemicals in the lungs and airways, which can play a role in the development of: Bronchitis Bronchitis is an inflammation of the lining of the bronchial tubes the tubes connecting the lungs to the nose and mouth

Many doctors do not use brush biopsies because while they are very easy, they may need a scalpel biopsy to confirm the results if the brush biopsy is positive

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Smokers who use outside help or treatments fare better luck, with success rates of 25% to 35%