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In contrast, an increase in nitric oxide production has been observed in human monocytes and macrophages [46]

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Similar content being viewed by others Background Multiple meta-analyses have reported that a history of cigarette smoking is significantly associated with reduced bone mineral density (BMD), increased risk of fracture and reduced fracture healing in comparison to non-smokers of the same age, sex and body mass index (BMI) [1,2,3,4]

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