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The cultivation of tobacco is traced back to 5,000 BC, whereas its usage has been recorded for over 8,000 years

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It has been known to produce anxiety, tension, excitation, insomnia, and, in larger doses, cause a dangerously elevated heart rate, high blood pressure, trouble breathing, nausea and vomiting, tremor, and dizziness

A priority of the Meaningful Measure 2.0 Framework is transforming measures to improve quality measure efficiency by transitioning to digital measures and using advanced data analytics