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The network, which included the Rice-MD Anderson team and five teams across the world, used a comparative modeling approach in which they constructed detailed cigarette smoking histories for people born from 1890 through 1970, and then related the histories to lung cancer mortality in mathematical models

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and "complex aphthae", accounting for 5% of cases, where ulcers may be present on the genital mucosa in addition to mouth, healing is slower and pain is more severe

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