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Smoking rates have been dropping for years, but the habit remains the leading cause of preventable death and disability in the United States, responsible when combined with secondhand smoke for about 1 in 5 deaths, according to the Centers for Disease Control and Prevention

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Strengths and limitations Strengths of this study include a large sample size (informed by an a priori power calculation), its double-blind, randomized, double-placebo-controlled, crossover design, and use of well-validated tasks