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Association of smoking with liver fibrosis and mortality in primary biliary cholangitis

In line with this, it has been observed that cigarette smoke induces the release of TNF- in an in vitro macrophage model system 56 , but others found no increased release of TNF- peripheral blood mononuclear cells to cigarette smoke extracts 57

Regardless of the causative pathway (or combination thereof), integrating structural and functional neuroimaging results may provide insight into the neurobiological processes potentially contributing to the initiation, escalation, and/or maintenance of cigarette smoking