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Ethics statement The studies involving human participants were reviewed and approved by Institute Ethics Committee (IEC), Indian Institute of Science Education and Research (IISER), Bhopal, India

Other factors like alcohol use, obesity, and acid reflux also contribute but smoking remains the most significant preventable cause

The federal Centers for Disease Control and Prevention says smokeless tobacco can cause cancer, oral health problems and nicotine addiction, and stresses it is not a safe alternative to smoking

Its not only a psychological challenge to put down cigarettes for good but a physical addiction too