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Methylation of DNA may do so either directly, through physical impediment of protein binding, or indirectly, through chromatin remodeling and its effect on DNA accessibility for proteins that regulate DNA transcription (Portela and Esteller, 2010)

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[63] [64] [65] [66] A fourth such location opened in September 2017, in Charlottesville, Virginia, directly across the street from the University of Virginia