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All types of subjects were included and divided into different groups including healthy subjects, obese subjects and others, to clarify the cross-effect between IF and subjects under different physiological and pathophysiological situations, including pregnancy, perioperative periodendocrine disease, cancer and autoimmune diseases

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High mobility group box 1 (HMGB1), RAGE, TLR4, NF-B and pNF-B expression reduction in mouse skin tissues and the decreased expression of pro-inflammatory cytokines TSLP, IL-4, IL-6, IL-13, IL-31 and TNF- was also observed [190]