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It involves physical and psychological reliance, leading to persistent cravings and withdrawal symptoms

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They write (and for readability I have deleted (bracketed information about the statistical confidence intervals from this description): "In 1964-2012, an estimated 17.7 million deaths were related to smoking, an estimated 8.0 million fewer premature smoking-related deaths than what would have occurred under the alternatives and thus associated with tobacco control (5.3 million men and 2.7 million women)