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Magnified: The face becomes bigger and bigger as it floats up, while the friend's face seems to be replaced by a skull-like pair of holes where the eyes used to be Amused: As they watch the scene unfolding on the phone in front of them, Dorrit and her friend erupt into a fit of laughter On her head, her friend's face has disappeared in the smoke, revealing a creepy skull-like pair of holes over where the eyes should be

Moreover, POU2F3 KO cultures exhibited strong depletion in the number of likely ionocytes (FOXI1 + ) and PNECs ( GRP + ) as assessed by wholemount IF or FISH microscopy, respectively (Fig