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In any of the non-purified CBD products that have therapeutic utility, it is difficult to tell whether the benefit of the product arises from CBD as the active pharmaceutic ingredient (API), or as a consequence of the other chemicals present, or as a consequence of any interaction (pharmacodynamic or pharmacokinetic) between the compounds (referred to as the entourage hypothesis)

It is used after NICODERM Step 2 for both heavy and light smokers

2020-2029 Statista: Average revenue per unit (ARPU) in the e-cigarettes segment of the tobacco products market United States from 2019 to 2029 Statista: Revenue of the e-cigarettes industry Worldwide 2019-2029 Statista: Share of e-cigarette smokers in 56 countries & territories worldwide, as of February 2024

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