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Cotinine , nicotine's primary metabolite, has a significantly longer half-life of about 15 to 20 hours

This screening criterion using the cutoff value of 0.25 follows the Purposeful Selection of Covariates strategy, which aims to retain not only statistically significant variables but also potential confounders that may not demonstrate a strong association in univariable analysis but could become important in the multivariable model

Put the filter on one end of the paper where your mouth will be

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