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The idea is much older than that: as far back as 1988, a paper in the journal Science argued that social relationships, or the relative lack thereof, constitute a major risk factor for healthrivalling the effect of well established health risk factors such as cigarette smoking

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Ischaemic heart disease/myocardial infarction Three epidemiological studies, all based on data from the Swedish construction workers cohort, have reported an increased risk of myocardial infarction associated with current snus use [34,35,36]