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insulin is broken down by the stomach acid Concentration the higher the concentration, the more drug that is absorbed (usually!) Ionisation ionised particles cannot diffuse across membranes this plays a part in the mechanism of action for local anaesthetics Solubility drugs that are more polar (see below) are less readily absorbed through the lipid bilayer of the cell membrane Physical state of the drug e.g

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Swiss National Science Foundation (grant 32473B_162608)

Can BPC-157 cross the nasal mucosa into systemic circulation