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104, 105 TLR2 recognizes not only peptidoglycans from Gram-positive bacteria and bacterial lipopeptides, but also endogenous danger signals, such as 70-kDa heat-shock protein (the latter is known to be released in smoke-exposed airways 104 )

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However, we understand your concerns around refill accessibility, as we are not in a position to know the extent to which all other brands are making refill parts available

This ranges from a staggering 69 per cent in Kiribati, to 50 per cent in in Albania, Cyprus, Kyrgyzstan and Latvia, 45 per cent in Greece, Mongolia and Republic of Moldova and 41 per cent in Ukraine, the Russian Federation, Bangladesh and Samoa