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Abstract Positron emission tomography (PET) has convincingly provided in vivo evidence that psychoactive drugs increase dopamine (DA) levels in human brain, a feature thought critical to their reinforcing properties

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32 Controlling for all covariates (Model 3) showed a weaker but nonetheless persistent negative association between smoking and cortical thickness, which is compatible with part of the association being due to the direct neurotoxic effects of cigarette smoking