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Now the Food and Drug Administration is taking the first step toward possibly limiting their use in tobacco products

E-cigarettes can directly damage airway epithelial cells, disrupt tight junctions, and cause epithelial barrier dysfunction [42]

As mentioned above, nicotine selectively activates nicotinic acetylcholine receptors (nAChRs), particularly those containing the 42 and 7 subunits, which in turn modulate dopamine, glutamate, serotonin, gamma-aminobutyric acid (GABA), and acetylcholine pathways associated with enhanced cognitive processing