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Marys , 9 June, 1698, Pirates in Their Own Words , Ed Fox, editor, p

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And though the term hypocrite may not be entirely appropriate, that ever-declining, but a still sizable, group within the profession who smoke have reason to be uncomfortable when the subject of smoking and health is discussed

This failure of therapeutic action should not be compensated for by increasing the dose in smokers as this might result in the production of toxic, even potentially mutagenic estrogen metabolites - compounds recently associated with a higher risk of breast cancer