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Resveratrol has been reported to potently inhibit P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), and organic anion transporter 1/3 (OAT1/OAT3) [154]

Reports of severe adverse events include allergic reactions ranging from mild rashes to anaphylactic shock, kidney dysfunction particularly with high doses or prolonged use, liver toxicity in susceptible individuals, and thyroid dysfunction affecting hormone regulation

Tirzepatide vs Semaglutide Dosage: How These Medications Are Prescribed Both medications require gradual dose escalation (called titration) to minimize gastrointestinal side effects

Furthermore, this interpretation is also supported by another study that has reported an association between the C-allele of rs1143634 in IL1B and higher serum IL-1 level and a lower response rate to infliximab therapy among patients with CD