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Surgeon General agrees, listing several ingredients and additives that could be harmful to your body: Ultrafine particles that you can inhale deep into your lungs Flavorants, like diacetyl, which can contribute to severe lung issues Heavy metals like tin, lead and nickel, which can cause poisoning Nicotine, the extremely addictive main ingredient that is linked to heart disease What Does the Research Say

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Thats not entirely clear, said Wang, who is also an associate professor of pediatrics at the University of Colorado Anschutz Medical Campus in Aurora, Colorado