Sermorelin operates as a synthetic growth hormone-releasing hormone (GHRH) analogue, mimicking the natural hormone produced by the hypothalamus
However, the Internet is filled with unsubstantiated claims that the peptide can cause unique and proven benefits such as: Improvements in muscle mass and muscle building body fat loss and reduced body weight improved body appearance faster recovery from injuries improved energy levels better physical performance increased ligament strength better muscle recovery after workouts improved cognition Improved bone density tissue regenerative properties The only plausible health benefits supported by any research are those observed in test animals, including reduced muscle damage during activity, muscle-sparing effects, increased organ growth, and weight gain
That is why tesamorelin carries FDA approval as EGRIFTA, EGRIFTA SV, and EGRIFTA WR for that specific use
In vitro study corroborated that the suppression of the ROS/TXNIP/HIF-1 pathway, which was presumably associated with the mitochondrial dysfunction in ferroptosis, fosters the ratio of retina-specific Treg cells, notably attenuating ocular inflammation and optic disc edema (54)
