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"In addition," asserts the Pierce study, "different measurement methods may result in different outcomes between randomized trials and population-based studies." Clinical trials compared apples to oranges

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As shown in Table 1, under the ISO puffing regime, ILUMA emitted a statistically significant higher amount of acetaldehyde than GLO, a higher amount of propionaldehyde compared to IQOS, PULZE, LIL and GLO and a higher amount of butyraldehyde compared to PULZE, LIL and GLO

Routine screening is not currently recommended, but may be beneficial in individuals at high risk, such as heavy smokers