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Most studies were observational ( n = 352), using cross-sectional (207), longitudinal (97), cohort (47) or casecontrol (1) designs
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Transcutaneous vagus nerve stimulation (tVNS) devices are also being studied as noninvasive tools to activate the vagal anti-inflammatory reflex (through acetylcholines action on 7 nicotinic receptors on immune cells)
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