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[4] The human act of "compensating" is perhaps the most important area in which the ISO machine-smoking method yields misleading results

When assessing the emissions of various chemicals from premium cigars, it is important to understand how consumers are using them in natural settings (real-life conditions)

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Wilson, Tobacco Constituents - Their Importance in Flavor and Fragrance Chemistry, Perfumer & Flavorist, 5(1), 27-51 (1990)