A comparison of semaglutide and tirzepatide Feature Semaglutide Tirzepatide FDA Approval Year 2017 (injection), 2020 (oral) 2022 Average Weight Loss ~1015% of body weight ~1520% of body weight Dosage Forms Weekly injection, oral tablet Weekly injection only Common Side Effects Nausea, vomiting, diarrhea, constipation Nausea, vomiting, diarrhea, constipation Frequency Weekly (injection), daily (oral) Weekly injection Cost (approximate) $900$1,200/month $1,000$1,300/month (Keep in mind that numbers are averages
Adequate calories: Very severe caloric restriction accelerates muscle loss
Amino Acids 50:12691278 Funding This study received financial support from the National Natural Science Foundation of China (Grant No
Pre-existing gallstones do not automatically contraindicate GLP-1 use, but they do require baseline imaging, symptom monitoring, and provider oversight