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Though not tested in patients with PAD specifically, NRT has been shown to be safe in patients with established CVD (60)

Nicotine included 15, 30, and 45 mg doses nicotine-patches on the market were evaluated in terms of safety profiles and it was shown that the use of high doses of transdermal nicotine was safe in dependent smokers and could reduce exposure to the other toxicants of tobacco (84)

Then they use chemical science to make it more addictive, and spend their victims' "death tax" money on lawyers and lobbying money in order to successfully cover their crimes