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Abbreviations BS: Beighton score cEDS: Classical Ehlers-Danlos syndrome clEDS: Classical-like Ehlers-Danlos syndrome CTP: Connective tissue panel EDS: Ehlers-Danlos syndrome gJHM: Generalized joint hypermobility HCTD: Heritable connective tissue disorder hEDS: Hypermobile Ehlers-Danlos syndrome JHM: Joint hypermobility LOVD: Leiden Open Variation Database MLPA: Multiplex ligation-dependent probe amplification MRI: Magnetic resonance imaging MVP: Mitral valve prolapse NGS: Next generation sequencing NMH: Neurally mediated hypotension POTS: Postural orthostatic tachycardia syndrome QoL: Quality of life SD: Standard deviation vEDS: Vascular Ehlers-Danlos syndrome References Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, et al