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Although the human relevance of these findings remains uncertain, as human C-cells have lower GLP-1 receptor expression compared to rodents, the potential risk necessitates avoiding this medication in patients with any personal or family history of medullary thyroid carcinoma

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310 Similar effects are observed after transgenic deletion of Ccl2 specifically from astrocytes, which showed little effects early in EAE but demonstrated that astrocyte Ccl2 sustains disease symptoms and inflammation during chronic EAE, making it a therapeutic target

We recommend using the smallest appropriate gauge, typically 23-25g