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Regulatory, integrative and comparative physiology 300, R11261133, doi: 10.1152/ajpregu.00687.2010 (2011)

Further optimization of GLP-1 analogues to permit once-weekly time action led to the discovery of Fc protracted dulaglutide and the fatty diacid acylated semaglutide

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In the retatrutide vs tirzepatide comparison, retatrutide appears more aggressive in early research, but tirzepatide currently has the advantage in regulatory approval, real-world availability, and longer safety follow-up