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This compound is more stable than O 2 - , and it can penetrate cell membranes ( ), singlet oxygen (O 2 1 ), and ozone (O 3 ) with strong bactericidal properties ( 2 - + H 2 O 2 OH - + OH - + O 2 ) and the Fenton reaction (H 2 O 2 + Fe 2+ Fe 3+ + OH - + OH - ) with the participation of pro-oxidant ions of transition metals (mostly Fe 2+ /Cu 2+ ) ( In bronchial asthma, ROS act as mediators of asthmatic inflammation and deliver direct pro-asthmatic effects ( The toxic effects of ROS are mitigated by antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), as well as non-enzymatic antioxidants such as glutathione (GSH), vitamins C and E, and uric acid

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Gao W, Huang Z, Duan J, Nice EC, Lin J, Huang C

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