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Review of the Negative Health Consequences of Cigarette Smoking In determining whether FDA should, as authorized by section 4(d) of the FCLAA, adjust the format, type size, color graphics, and text of any of the label requirements to promote greater public understanding of the risks associated with the use of tobacco products, FDA reviewed the scientific literature as well as available nationally representative data on current consumer knowledge and misperceptions about the health risks of smoking

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10.1056/NEJM198811173192005 Freeman DJ, Packard CJ: Smoking and plasma lipoprotein metabolism