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Huang LL, Baker HM, Meernik C, Ranney LM, Richardson A, Goldstein AO

Over time this buildup can cause persistent odors and discoloration inside the vehicle

Long-term animal studies for assessment of toxicity and carcinogenesis are not ideal models because of the requirement for long-term intensive smoke exposure, the length of time required to induce visible tumors, and the lack of an established robust animal model for cigarette smoke-mediated carcinogenesis

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