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In addition, cotinine at 10 M was found to lack significant binding to or action on more than 70 molecular targets, including major neurotransmitter receptors and transporters (adenosine, adrenergic, dopamine, GABA, glutamate, glycine, histamine, muscarinic, opioid, serotonin, sigma 1 and 2), ion channels (Ca 2+ , K + , Na + ), second messengers (e.g., nitric oxide), prostaglandins (e.g., leukotriene and thromboxane), brain/gut peptides (e.g., angiotensin II, bradykinin, endothelin, neurokinin, neuropeptide), and enzymes (acetylcholine esterase, phosphodiesterase, protein kinase A and C) (Terry et al., 2015a)
The companys strategy has evolved from product-centric to purpose and audience-centric, creating resonance across markets
Knees on cold tile, palm pressed to palm, fingers interlaced as if to hold myself together, I rocked back and forth, gently banging my forehead against the side of the hospital mattress
