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Melanotan-2 Side Effects MT-2's multi-receptor activation causes significantly more side effects: Nausea (very common, especially during loading the #1 complaint) Facial flushing (common, more intense than MT-1) Spontaneous erections (common in men, MC4R-mediated) Increased libido (both sexes, MC4R-mediated) Appetite suppression (common, MC4R-mediated) Fatigue/drowsiness (common post-injection) Mole/freckle darkening (more pronounced than MT-1) Injection site pain (variable) The nausea during MT-2 loading is significant enough that many users inject before bedtime to sleep through the worst of it

Oxidative stress Oxidative stress has been implicated in the development of ventricular tachycardia and fibrillation, particularly in situations wherein the blood supply to the heart is temporarily interrupted and then restored (eg, following a heart attack) (Wolin 2005)

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Studies have linked the hormone in Melanotan to changes in existing moles and the development of new ones, urological issues like erectile dysfunction, and melanoma skin cancer