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Regulation of glutamine metabolism (glutaminolysis) Glutamine is the most abundant plasma amino acid and, in many tumors, becomes an indispensable nutrient: its carbon feeds the tricarboxylic-acid cycle as -ketoglutarate, its nitrogen donates to nucleotide and hexosamine synthesis, and its catabolism through malic enzyme yields NADPH for redox control and lipid biosynthesis [104]
The popularity of GLP-1 drugs has surged worldwide, particularly as weight-loss treatments sold under different brand names
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