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To investigate COPD heterogeneity, we profiled lung tissue by single-nucleus RNA sequencing from 141 study participants (1,516,727 nuclei) and identified shifts in cell composition and emergent cell states that correlated with lung function, emphysema and composite symptom scores

Because populations seldom reach damaging levels before late summer, manage the crop for early maturing and plan to defoliate by late September

While coping with these symptoms can still be challenging, understanding what to expect can help

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