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Implementing business compliance solutions can significantly reduce the risk of fines for selling tobacco to minors and the penalty for selling vape to minors

Responses were recorded on a Likert scale and categorized into agree (combining strongly agree and agree), disagree (combining strongly disagree and disagree), and do not know. Confirmed ONP users self-reported any previously identified use-related symptoms (24, 29, 30), including frequent coughing, oral irritation (e.g., white patches, gum irritation/recession, blisters), taste alteration, dry mouth, throat symptoms, or abdominal symptoms, with an option for no symptoms or other symptoms (A simplified table summarizing the described ONP survey items is provided in the Supplementary file)

Finally, we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials

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