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Moreover, the DNMT inhibitor 5-aza-2-deoxycytidine (AZA) can promote alternative activation, suppress inflammation by macrophages [114], and inhibit the constitutive activation of pro-inflammatory NF - B [115]

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Such a nationwide effect might overwhelm the expected effect from state-level tobacco control interventions.7 All US states had started taxing cigarettes by 1966 and these taxes have generally increased over time.8 However, there are large differences across US states in the implementation of cigarette excise taxes, which increase price of cigarettes

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