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However, nicotine or nicotinic agonists, as discussed above, may have significant therapeutic potentials including COVID19 [37, 38, 51, 58]

Consequently, endothelial dysfunction induced by e-cigarettes seems to occur even in the absence of nicotine, as it could be induced by the toxic metals contained and by the reduction in antioxidants such as vitamin E, for example [41]

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In addition, a significant interaction was found to occur on the dependent variable (stress and depression symptoms) due to respondents of Chinese descent showing high levels of stress and depression symptoms when using single tobacco products