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To examine for statistically significant changes in outcomes from usual brand cigarettes to NNC SPECTRUMs, and to assess for group differences in these changes by usual brand rod length, Wald tests were used for the inference on fixed-effect parameters

however, the water-soluble sugar content decreases continually, which may be due to the consumption of sugar substances by microorganisms on the tobacco leaves

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The company said there would be an impact from the fall in sterling against the dollar and that trading remained "challenging" in a number of key markets