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Risk of bias was assessed using the Cochrane Risk of Bias (ROB) tool for randomized controlled trials (RCTs) and the Risk of Bias Assessment Tool for Non-randomized Studies 2.0.7 For consistency, ROB 1.0 was used if applied in previous reviews, whereas the ROB 2.0 tool was used for de novo systematic reviews.8, 9 Two reviewers independently assessed each study, and any discrepancies were resolved through discussion

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This is particularly the case for young people who are taking up e-cigarettes without having smoked before. Isabel Saraiva, former chair of the European Lung Foundation, who sadly passed away in 2024, previously commented: As an ex-smoker, I understand that it is tempting for people, who think that it will be easier to stop smoking by substituting cigarettes with e-cigarettes

Did you know that a recent survey shows a shocking ninefold increase in the number of people using vapes from 2021 to 2023