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However, and in line with our experience, other authors did not find these structures in weak positive reactions.8 Corazza et al.5,6 found vascular structures to be highly sensitive and prevalent in allergic reactions and to be constant in weak positive reactions, with a negative predictive value of 100%, suggesting that the absence of such reactions would almost rule out a diagnosis of allergic reaction.6 In contrast, other studies only report vascular abnormalities that can be distinguished from basal erythema in little more than 20% of cases (our experience is similar).8 As for morphology, dotted vessels (Fig

Addiction to nicotine is physical, mental, and behavioral

Dopamine is a neurotransmitter that the brain releases when the pleasure center is triggered

This change in attitude is encouraging smokers to switch to vaping