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It is then fitted with a custom Teflon tenon and a Lucite stem

We use a Burden of Proof meta-analysis to generate conservative risk estimates and find weak-to-moderate evidence that tobacco chewers have an increased risk of stroke, lip and oral cavity cancer, esophageal cancer, nasopharynx cancer, other pharynx cancer, and laryngeal cancer

(While nicotine pouches dont contain tobacco, the FDA does still regulate them.) An FDA spokesperson noted that the agencys review of new products looks for both potential benefits and risks like whether it offers adults a less harmful alternative to other tobacco products, or whether it introduces kids to them

We would also like to thank Muhammad Ali Akbar Khan (AKU) and Taha Shaikh (AKU) for reviewing the final manuscript