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However, we now have reasonable epidemiological evidence in humans that lessens the impact of the Authors findings in rodents

Nicotine obtained through smoking is even more addictive

Data from national Youth Risk Behavior Surveys (YRBS) show that while current use of combustible tobacco products (cigarettes and cigars) dropped dramatically from 2001 to 2013 among all high school students (31.5 percent to 19.5 percent), current use of smokeless tobacco remained unchanged among non-athletes (5.9 percent) and increased among athletes (10 percent to 11.1 percent)