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To test these hypotheses, along with colleagues Sameer Jauhar, Pedro Gurillo Muoz and Robin Murray from Kings College London, we conducted a review of 61 observational studies comprising almost 15,000 tobacco users and 273,000 non-users

However, there have also been documented cases of serious lung injury associated with vaping, so reduced harm does not mean harmless, though much of the harm from vaping is associated with a chemical called vitamin E acetate which has been used to mix illicit substances like THC into e-liquids

Footnotes Funding: This work was supported in part by the National Institute of General Medical Sciences Training grant T32GM080178, the National Cancer Institute grant R01CA141307, and by the National Human Genome Research Institute grant U01HG004798 for the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) study