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Interleukin (IL)-1b and TNF-alpha are two inflammatory markers that have significantly risen in animal models as a result of increased stress hormone production (142)

Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, disruption in brain energy metabolism, and higher serum levels of glutamate and homocysteine